Stephen J. Usala,William C. Biggs,Faye OBrien-Usala
申请号：
US14133531
公开号：
US20150164484A1
申请日:
2013.12.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are methods for assessing the period of potential fertility, days of maximum fertility, and transition to the infertile phase via measurement and processing of vaginal CA125 (MUC16) levels. In one embodiment, the fertile and infertile phases of the ovulatory normal female menstrual cycle are defined by a pattern or signature of day-specific vaginal CA125 levels. Suitably, signatures are based upon daily cotton swab collection of vaginal epithelial and fluid plus subsequent assay of CA125. Day-specific vaginal CA125 assay levels increase during the period of potential fertility and reach a maximum with inflection point generally before and near the time of ovulation. Derived functions of day-specific vaginal CA125 are used to predict fertility, enhance conception, and for birth control.
