Benzofusionados substituted Compounds, Selective Androgen receptor modulators and their use in the treatment of diseases such as anorexia, anemia, arthritis, among others.
ANDERSON, JAMES THOMAS,CHEKLER, EUGENE LVOVICH PIATNITSKI,ELLSWORTH, EDMUND L.,ERICKSON, BRUCE KIPP,GILBERT, ADAM MATTHEW,RICKETTS, ANTHONY P.,THOMPSON, DAVID P.,UNWALLA, RAYOMAND JAL,VERHOEST, PATRIC
申请号：
CL2015001495
公开号：
CL2015001495A1
申请日:
2015.06.03
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or &mdash；CR0&mdash；, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is &mdash；CRe&mdash；, or, &mdash；N&mdash；, where Re is hydrogen, C1-C6 linear or branched chain alkyl, etc.； R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.； R2 are independently hydrogen or C1-C6 linear or branched chain alkyl； R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc.； R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.； R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.； R9 and R10 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.； Q is &mdash；CO&mdash；, &mdash；(CH2)q&mdash；, &mdash；(CHRs)q&mdash；, or &mdash；(CRsRt)q&mdash；, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2, or 3； and, where n is 0, 1, 2, 3, 4 or 5； or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds； and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.COMPUESTOS DERIVADOS DE ISOQUINOLIN-1-CARBONITRILO, (1,1-DIÓXIDO-[1,2,5-TIADIAZOLIDIN Ó 1,2-TIAZOLIDIN Ó 1,2,6-TIADIAZIN]-2-IL)-ISOQUINOLIN-1-CARBONITRILO, (5,7-DIAZASPIRO[2.5]-OCT-5-IL)-ISOQUINOLIN-1-CARBONITRILO, ENTRE OTROS, QUE MODULAN LA ACTIVIDAD DE UN RECEPTOR DE ANDRÓGENOS； ÚTILES PARA EL TRATAMIENTO DE ANEMIA, ANOREXIA, ARTRITIS, OSTEOPATÍA, CAQUEXIA, DETERIORO MUSCULO-ESQUELÉTICO, ENTRE OTRAS.
