CHEKLER, EUGENE LVOVICH PIATNITSKI,GILBERT, ADAM MATTHEW,UNWALLA, RAYOMAND JAL,VERHOEST, PATRICK ROBERT,ANDERSON, JAMES THOMAS
申请号：
SG11201609050U
公开号：
SG11201609050UA
申请日:
2015.05.18
申请国别(地区):
SG
年份:
2016
代理人:
摘要：
The present invention relates to a compound of Formula 1, 2 or 3: I II III wherein A is N or -CR0--, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is -CRe --, or, -N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R2 are independently hydrogen or C1-C6 linear or branched chain alkyl； R3 and R4 are independently hydrogen, C1C6 linear or branched chain alkyl, etc.；. R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.； R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.； R9 and R10 are independently hydrogen or C1- C6 linear or branched chain alkyl, etc.； Q is --CO--, --(CH2)q--, --(CHRs)q--, or -(CRsRt)q- -, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl； where q is 0, 1, 2, or 3； and, where n is 0, 1, 2, 3, 4 or 5； or, a pharmaceutically acceptable salt thereof, for the treatment of certain diseases, particularly those affected or mediated by the androgen receptor； to compbinations comprising such compounds with a second pharmaceutically active ingredient； to compositions containing such combinations； and to such combinations for the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.
