Christopher Joseph Sinz;Emma R. Parmee;Ronald M. Kim;Olga A. Ziouzina
发明人:
Ronald M. Kim,Emma R. Parmee,Christopher Joseph Sinz,Olga A. Ziouzina
申请号：
US12711854
公开号：
US08507512B2
申请日:
2010.02.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This inventions relates to compounds having the structure Formula Iand pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
