Disclosed is a pharmaceutical formulation for use in the treatment, amelioration of symptoms or both of Acquired Immune Deficiency Syndrome (AIDS) or a HIV infection in a subject comprising three components: the first component comprising a sterile injectable polymannan extract formulation comprising one or more aloe polysaccharides, wherein the aloe polysaccharides comprise large chain, very-large chain polysaccharides, or any combinations thereof a molecular weight ranging from 2,000,000-10,000,000 Daltons and the second component comprising one or more aloe anthraquinones, diacetyl anthraquinone derivatives, and combinations and modifications thereof and the third component adapted for oral administration comprising a freeze dried aloe powder, an aloe juice, an aloe gel or a combination wherein the powder is administered as is or after reconstitution in a liquid.
