LEE, MIN SUN,이민선,KIM, HUN TAEK,김훈택,LEE, BONG YONG,이봉용,PARK, MAHN HOON,박만훈,LIM, YUN JUNG,임윤정
申请号：
KR1020110106392
公开号：
KR1020120047771A
申请日:
2011.10.18
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A fusion protein containing blood coagulation factor IX and transferrin is provided to enhance specific activity and to treat using FIX.CONSTITUTION: A fusion protein contains human-derived factor IX(FIX) and transferring. The FIX is denoted by amino acid sequence of sequence number 1. A functional equivalent has substantially same activity with FIX and is prepared by deleting, inserting, or substituting an amino acid residue of sequence number 1. The transferring is a polypeptide of sequence number 2 or functional equivalent thereof. The fusion protein has a linker between FIX and transferring. The linker is a peptide of amino acid sequence 3 or 4.COPYRIGHT KIPO 2012본 발명은 혈액응고 인자 IX(FIX) 및 트랜스페린을 포함하는 융합 단백질에 관한 것으로서, 본 발명에 따른 융합 단백질은 천연형 FIX에 비해 증가된 비활성을 가지므로 FIX을 이용한 치료에 유용하게 사용될 수 있다.
