Andrej Bastarda;Samo Pirc;Klemen Kocevar;Rok Grahek;Miha T. Jaklic
发明人:
Rok Grahek,Andrej Bastarda,Miha T. Jaklic,Klemen Kocevar,Samo Pirc
申请号：
US13263051
公开号：
US20120088774A1
申请日:
2010.04.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention belongs to the field of pharmaceutical industry and relates to dosage forms comprising active pharmaceutical ingredients (API) such as tadalafil, simvastatin, fenofibrate and lovastatin that are practically insoluble in water, adsorbed on a carrier. Furthermore it relates to an adsorbate comprising API being practically insoluble in water and to a process for the preparation of said adsorbate with non-polar solvent (s) such as chlorinated hydrocarbon, diisopropylethes and hexane. Furthermore the invention relates to a process for the preparation of the dosage form, as well as to the use of the adsorbate for the preparation of the dosage form. Moreover it relates to the dosage form for use in the treatment of erectile dysfunction, human immunodeficiency virus (HIV) infections and/or Acquired Immune Deficiency Syndrome (AIDS).
