Disclosed are synthetic nanocarrier compositions, and related methods, for treating diseases in which generating a Th1 -biased immune response is desirable. In an aspect, the invention relates to a composition for treatment of a condition comprising: synthetic nanocarriers comprising (1) an immunofeature surface, an (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocamers and a pharmaceutically acceptable excipient wherein the immunofeature surface does not comprise antigen that is relevant to treatment of the condition in an amount sufficient to provoke an adaptive immune response to the antigen that is relevant to treatment of the condition. In another aspect, the invention relates to a method comprising: identifying a subject suffering from a condition providing a composition that comprises synthetic nanocarriers that comprise (1) an APC targeting feature, and (2) a Th1 biasing immunostimulatory agent coupled to the synthetic nanocarriers and a pharmaceutically acceptable excipient and administering the composition to the subject wherein the administration of the composition does not further comprise co-administration of an antigen that is relevant to treatment of the condition. In yet another aspect, the invention relates to a method comprising: providing a composition comprising synthetic nanocarriers that comprise a Th1 biasing immunostimulatory agent and an APC targeting feature administering the composition to a subject and administering an antigen to the subject to which a Th1 biased response is desired at a time different from administration of the composition to the subject wherein administration of the antigen comprises passive administration or active administration.Se divulgan composiciones nanoportadoras sintéticas y métodos relacionados para tratar enfermedades en las cuales se desea generar una respuesta inmune sesgada hacia Th1.
