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Method for down-regulating gene expression in fungi
专利权人:
Thierry Andre Oliver Eddy Bogaert;Katherine An Hilde Mortier;Phuay-Yee Goh;Marc Van De Craen;Yee-Ling Khu;Marc Georges Logghe
发明人:
Marc Van De Craen,Phuay-Yee Goh,Marc Georges Logghe,Yee-Ling Khu,Katherine An Hilde Mortier,Thierry Andre Oliver Eddy Bogaert
申请号:
US12778278
公开号:
US08865968B2
申请日:
2010.05.12
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
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