Hematopoietic stem cells and methods of treating neovascular diseases of the eye using the cells

• 收藏
• 分享

专利权人:

ザ スクリプス リサーチ インスティチュート

发明人:

マーテイン・フリードランダー,アツシ・オタニ,カレン・ダシルバ

申请号：

JP2010142292

公开号：

JP5385219B2

申请日:

2010.06.23

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

Isolated, mammalian, bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin<；SUP>；-<；/SUP>； HSC) contain endothelial progenitor cells (EPC) capable of forming retinal blood vessels. At least about 50% of the cells in the isolated Lin<；SUP>；-<；/SUP>； HSC population include cell surface markers for CD31 and c-kit. Up to about 8% of the cells can include the Sca-1 cell marker, and up to about 4% of the cells can include the Flk-1/KDR marker. The isolated Lin<；SUP>；-<；/SUP>； HSC populations of the present invention are useful for treatment of ocular vascular diseases. The isolated Lin<；SUP>；-<；/SUP>； HSC populations that have been transfected with therapeutically useful genes are also provided, which are useful for delivering genes to the eye for cell-based gene therapy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/