DROHAN, Marian J.,DROHAN, William N.,GRIFFITH, Michael J.
申请号：
AU2014202989
公开号：
AU2014202989B2
申请日:
2014.06.03
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2014202989B220160707.pdf#####Abstract Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N- glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.
