Anders H. Berg;S. Ananth Karumanchi;Ravi I. Thadhani
发明人:
Anders H. Berg,S. Ananth Karumanchi,Ravi I. Thadhani
申请号：
US14131866
公开号：
US20140228296A1
申请日:
2012.07.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
