Children's Medical Center Corporation;Dana Farber Cancer Institute, Inc.
发明人:
ABRAHAM, Jonathan,HARRISON, Stephen,WUCHERPFENNIG, Kai
申请号：
EP17810953
公开号：
EP3468592A4
申请日:
2017.06.07
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention generally provides compositions and methods of treating or preventing an arenavirus infection, using an agent that inhibits binding of an arenavirus glycoprotein 1 (GP1) polypeptide to transferrin receptor 1 (TfR1). The invention also provides methods of designing or identifying therapeutic agents that bind to or target a GP1 receptor-binding site (RBS) to inhibit arenavirus attachment to a cell, and therapeutic agents identified using the methods.
