The present invention relates to the L-proline complex, monohydrate and crystal of a sodium-glucose contransporter 2 inhibitor. Specifically, the present invention relates to 1,6-anhydro-1-C-{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl] phenyl}-5-C-(hydroxymethyl)- β -L-idose pyranose L-proline (compound of formula (I), monohydrate , form A crystal and their preparation method thereof. The form A crystal of compound of formula (I) has good chemical stability and crystal stability, low toxicity and low residue of crystallization solvent, can be better used for clinical treatment.本發明涉及一種鈉-葡萄糖共同轉運蛋白2抑制劑的L-脯胺酸複合物、其一水合物及晶體。具體地,本發明涉及1,6-脫水-1-C-{4-氯-3-[(3-氟-4-乙氧苯基)甲基]苯基}-5-C-(羥甲基)-β-L-艾杜吡喃糖L-脯胺酸(式(I)複合物)、其一水合物、A型結晶及其製備方法。本發明所得到式(I)複合物)的A型結晶具備良好的化學穩定性和晶型穩定性,並且所用結晶溶劑低毒低殘留,可更好地用於臨床治療。由於本案的圖為試驗化合物的結果數據,並非本案的代表圖。故本案無指定代表圖。
