LU, TIANBAO,THOMAS P., MARKOTAN,ANNA C., MARONEY,JAN L., SECHLER,JEREMY M., TRAVINS,TUMAN W., ROBERT,RICHARD, ALEXANDER,RICHARD W., CONNORS,MAXWELL D., CUMMINGS,ROBERT A., GALEMMO,HEATHER RAE, HUFNAGE
申请号:
MYPI 20082265
公开号:
MY159523A
申请日:
2006.12.18
申请国别(地区):
MY
年份:
2017
代理人:
摘要:
THE INVENTION IS DIRECTED TO TRIAZOLOPYRIDAZINE COMPOUNDS OF FORMULA I: WHERE R1, R5, R6, R7, R8, AND A ARE AS DEFINED HEREIN, THE USE OF SUCH COMPOUNDS AS PROTEIN TYROSINE KINASE MODULATORS, PARTICULARLY INHIBITORS OF C-MET, AND THE USE OF SUCH COMPOUNDS TO REDUCE OR INHIBIT KINASE ACTIVITY OF C-MET IN A CELL OR A SUBJECT, AND MODULATE C-MET EXPRESSION IN A CELL OR SUBJECT, AND THE USE OF SUCH COMPOUNDS FOR PREVENTING OR TREATING IN A SUBJECT A CELL PROLIFERATIVE DISORDER AND/OR DISORDERS RELATED TO C-MET. THE PRESENT INVENTION IS FURTHER DIRECTED TO PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS OF THE PRESENT INVENTION AND TO METHODS FOR TREATING CONDITIONS SUCH AS CANCERS AND OTHER CELL PROLIFERATIVE DISORDERS.