Provided is a compound combination without side effect to liver for improving liver toxicity of acetaminophen (APAP) medicine, which includes (a) a pharmaceutically effective amount of acetaminophen and (b) a composition of combining one or more liver safe and pharmaceutically acceptable popular excipient compounds that can lower liver toxicity caused by liver enzyme CYP2E1 metabolism. The compounds are selected from the group consisting of: Tween 20, microcrystalline cellulose, dicalcium phosphate dihydrate, Brij 35, saccharin, mannitol, cremophor RH40, sucralose, crospovidone, sodium starch glycolate, eudragit S100, croscarmellose sodium, pluronic F68, menthol, low-substituted hydroxypropyl cellulos, pre-gelatinized starch, dextrates NF hydrated, citric acid, cremophor EL, aerosol 200, myrj 52, sorbic acid, lemon oil, hydroxypropyl cellulose, sorbitol, acesulfame potassium, hydroxypropyl methylcellulose, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, PEG 4000, PEG 2000 and so on, so as to lower the side effect of liver toxicity caused by acetaminophen.一種化合物用於去除對乙醯胺基酚(Acetaminophen,APAP)藥物肝毒性之用途,該化合物係選自於下列群組:Tween 20、微晶纖維素、磷酸氫二鈣、聚氧乙烯23月桂基醚、糖精、甘露醇、聚氧乙烯烷基醚、三氯蔗糖、吡咯烷酮、羥基乙酸澱粉鈉、丙烯酸樹脂S100、羧甲基纖维素鈉、聚氧乙烯聚氧丙烯、薄荷醇、低取代烴丙纖維素、預膠化澱粉、Dextrates NF hydrated、檸檬酸、蓖麻油聚氧乙烯醚、膠態二氧化矽、聚乙二醇單硬脂酸酯、山梨酸、檸檬油、羥丙基纖維素、山梨糖醇、乙鮮舒泛鉀、羥丙甲纖維素酞酸酯、單水合乳糖、麥芽糖糊精、Brij 58、Brij 76、Tween 80、Tween 40、PEG 400、PEG 4000、PEG 2000等。
