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New acetaminophen complex composition with no side effects on the liver
- 专利权人:
- ▲財▼▲団▼法人国防教育研究基金会
- 发明人:
- 胡幼圃,石▲東▼原
- 申请号：
- JP2016515604
- 公开号：
- JP2016520100A
- 申请日:
- 2013.11.13
- 申请国别(地区):
- JP
- 年份:
- 2016
- 代理人:
- 摘要：
- A new acetaminophen (APAP) complex composition that suppresses hepatotoxicity and has no side effects. (A) Acetaminophen at a pharmaceutically effective dose, and (b) Hepatic toxicity caused by the liver enzyme CYP2E1 metabolizing drug. A combination of compounds as one or more general excipients that is lowered and safe and pharmaceutically acceptable, the compound comprising sorbitan monolaurate； Tween 20 (Polyethylene glycol sorbitan monolaurate； Tween 20), microcrystalline cellulose, dicalcium phosphate dihydrate, polyoxyethylene (23) lauryl ether (Brij 35), saccharin, mannitol, polyoxyethylene Hydrogenated castor oil (40) (Cremophor RH40), sucralose, crospovidone, den Sodium starch glycolate, methacrylic acid copolymer S (Eudragit S100), croscarmellose sodium, polyoxyethylene (160) polyoxypropylene (30) glycol (Pluronic F68), menthol (Menthol) , Low-substituted hydroxypropyl cellulos, Pregelatinized starch, Dextrates NF hydrated, Citric acid, Polyoxyalkylene (C 24) castor oil Fatty acid ester (Cremophor EL), Aerosil 200, 2- (2-hydroxyethoxy) ethyl stearate (Myrj 52), Sorbic acid, Lemon oil, Hydroxypropyl cellulose (Hydroxypropyl cellulose) ), Sorbitol, acesulfamecaliu (Acesulfame potassium), Hydroxypropyl methylcellulose, Lactose monohydrate, Maltodextrin, Polyoxyethylene cetyl ether (Brij 58), Decaethylene glycol monooctadecyl ether (Brij 76), Polyoxyethylene sorbitan monooleate (twin 80) (Tween 80), polyoxyethylene sorbitan monopalmitate (twin 40) (Tween 40), polyethylene glycol 400 (PEG 400), polyethylene glycol 4000 (PEG 4000), and polyethylene Choose from groups such as Glycol 2000 (PEG 2000) to reduce the side effects of hepatotoxicity caused by acetaminophen.肝毒性を抑えて副作用のない、新しいアセトアミノフェン（Acetaminophen、APAP）複合組成で、（a）薬学的に有効な用量のアセトアミノフェン、及び（b）肝臓酵素CYP2E1代謝薬物がもたらす肝毒性を降下させ、且つ安全で、薬学的に許容可能な、一種類以上の一般賦形剤としての化合物の組合せであり、この化合物は、モノラウリン酸ソルビタンポリエチレングリコール（ツイン20）（Polyethylene glycol sorbitan monolaurate；Tween 20)、結晶セルロース（Microcrystalline cellulose）、リン酸二カルシウム二水和物（Dicalcium ph
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
