A robotic surgery system includes a mobile base (48) configured to be movably coupled to the operating room； a first robotic arm (34) coupled to the mobile base and comprising a mounting fixture (50) configured to be interchangeably coupled to a surgical tool and a first element (24) of a fluoroscopic imaging system comprising a source element and a detector element； a second element (26) configured to be repositionable relative to a patient tissue structure that may be placed between the first and second elements； and a controller (74) operatively coupled to the first robotic arm, the controller configured to receive signals from a sensing system operatively coupled to the controller, the sensing system (80) configured to detect motion of one or more sensor elements coupled to each of the first and second elements of the fluoroscopic imaging system and determine a relative spatial positioning between each of the first and second elements.
