Described is a vaccine composition comprising an effective amount of at least one polypeptide or at least one vector selected from the group of (a) a protein designated IdeSsuis, an analogue or a fragment thereof, (b) a protein designated rIdeSsuis, an analogue or a fragment thereof, (c) a vector with a polynucleotide inserted therein encoding the protein IdeSsuis, an analogue or a fragment thereof, (d) a vector with a polynucleotide inserted therein encoding the protein rIdeSsuis, an analogue or a fragment thereof and at least a pharmaceutical carrier, a diluent or an adjuvant. Described is further a method for producing a protein rIdessuis as a guest antigen in a vector or a different organism under condition suitable for expression of said recombinant protein. Described herein is further the use of the vaccine composition, according to any of claims 1 to 11, to perform a prophylactic or metaphylactic or therapeutic treatment of a Streptococcus suis infection in pigs. It has been shown that the vaccination of pigs using the protein rIdessuis alone as the sole antigen provides a protection for pigs infected by S. suisLa présente invention concerne une composition vaccinale comprenant une quantité efficace d'au moins un polypeptide choisi dans le groupe comportant IdeSsuis, rIdeSsuis, son analogue ou son fragment, ou un polynucléotide codant pour celui-ci. Cette composition vaccinale est utilisée dans le traitement prophylactique, métaphylactique ou thérapeutique d'une infection par le Streptococcus suis chez les porcs ou les humains.
