Described is a vaccine composition comprising an effective amount of at least one polypeptide or at least one vector selected from the group of (a) a protein designated IdeSsuis, an analogue or a fragment thereof, (b) a protein designated rIdeSsuis, an analogue or a fragment thereof, (c) a vector with a polynucleotide inserted therein encoding the protein IdeSsuis, an analogue or a fragment thereof, (d) a vector with a polynucleotide inserted therein encoding the protein rIdeSsuis, an analogue or a fragment thereof and at least a pharmaceutical carrier, a diluent or an adjuvant. Described is further a method for producing a protein rIdessuis as a guest antigen in a vector or a different organism under condition suitable for expression of said recombinant protein. Described herein is further the use of the vaccine composition, according to any of claims 1 to 11, to perform a prophylactic or metaphylactic or therapeutic treatment of a Streptococcus suis infection in pigs. It has been shown that the vaccination of pigs using the protein rIdessuis alone as the sole antigen provides a protection for pigs infected by S. suis
