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NON-AQUEOUS LIQUID COMPOSITION
专利权人:
SANTEN PHARMACEUTICAL CO.; LTD.
发明人:
YAMADA, KAZUHITO,URTTI, ARTO,BURMESTER, MECHTHILD
申请号:
PH12014501689
公开号:
PH12014501689A1
申请日:
2014.07.25
申请国别(地区):
PH
年份:
2014
代理人:
摘要:
A drug-dissolved non-aqueous liquid composition comprising a drug, dioleylphosphatidylcholine, tocopherol and an organic solvent, wherein the ratio of the blend concentration of dioleylphosphatidylcholine to that of tocopherol falls within the range from 75/25 to 25/75, the blend concentration of dioleylphosphatidylcholine falls within the range from 15 to 85 pcnt (w/w) and the blend concentration of tocopherol falls within the range from 15 to 85 pcnt (w/w). The phase of the non-aqueous liquid composition can be changed into a non-lamellar liquid crystal upon the contact with water, a phosphate buffer, a body fluid, a tear fluid or a vitreous fluid.
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