Composition in aqueous solution, useful in pharmaceutical insulin formulation for treating diabetes, comprises insulin and substituted anionic compounds, which consist of a backbone formed by saccharide units, linked by glycosidic bonds
Composition in aqueous solution, comprises insulin and substituted anionic compounds, which consist of a backbone formed by a discrete number (u) of 1-8 of identical or different saccharide units, linked by identical or different glycosidic bonds. The saccharide units consist of hexoses in cyclic form or open reduced form. The substituted anionic compounds comprise partially substituted carboxyl functional groups and unsubstituted carboxyl functional groups that are salifiable. Independent claims are included for: (1) pharmaceutical formulation comprising a composition in aqueous solution； (2) use of anionic functionalized compound for preparing pharmaceutical insulin formulation, after administration, to accelerate passage of blood insulin and to reduce blood sugar faster relative to a formulation free of anionic substituted compound； and (3) preparing formulation of human insulin and insulin analog whose onset of action in humans is lower than that of the reference formulation in the same concentration of insulin in the absence of anionic substituted compound, comprising adding an anionic compound to the formulation. ACTIVITY : Antidiabetic. MECHANISM OF ACTION : None given.L'invention concerne une composition en solution aqueuse, comprenant de l'insuline et au moins un composé anionique substitué choisi parmi les composés anioniques substitués constitués d'un squelette formé d'un nombre discret u compris entre 1 et 8 (1 ≤ u ≤ 8) d'unités saccharidiques identiques ou différentes, liées par des liaisons glycosidiques identiques ou différentes, lesdites unités saccharidiques étant choisies dans le groupe constitué par, les hexoses, sous forme cyclique ou sous forme réduite ouverte, ledit composé comportant des groupes fonctionnels carboxyles partiellement substitués, les groupes fonctionnels carboxyles non substitués étant salifiables. Elle concerne également une formulation pharmaceutique comprenant une composition selon l'une quelconque des revendications précéden
