Disclosed herein are compositions and methods for modulating cell surface receptor signaling by specifically recruiting membrane phosphatases to a proximity of receptors of interest. This novel methodology, termed Receptor Inhibition by Phosphatase Recruitment (RIPR), represents a new approach to reducing and suppressing signal by receptors that signal through phosphorylation mechanisms. More particularly, the disclosure provides novel multivalent protein-binding molecules that specifically bind a cell surface receptor and antagonize the receptor signaling through recruitment of a phosphatase activity. Also provided are compositions and methods useful for producing such molecules, as well as methods for the treatment of diseases associated with the inhibition of signal transduction mediated by cell surface receptor.本發明揭示藉由特定地將膜磷酸酶補充至相關受體鄰近處來調節細胞表面受體信號傳導之組合物及方法。此新穎方法稱為藉由磷酸酶補充之受體抑制(RIPR)，其代表藉由經由磷酸化機制傳導信號之受體降低及抑制信號之新方法。更特定言之，本發明提供經由補充磷酸酶活性特異性結合細胞表面受體且拮抗受體信號傳導之新穎多價蛋白結合分子。亦提供適用於產生此類分子之組合物及方法，以及用於治療與細胞表面受體介導之信號轉導之抑制相關之疾病的方法。
