The invention relates to a pharmaceutical composition based on an active principle, such as primarily Sucralfate, for the treatment of disorders related to gastrointestinal irritation such as gastric ulcers, duodenal ulcers, acute gastritis, symptomatic chronic gastritis, gastropathy related to anti-inflammatories, reflux esophagitis, characterized by comprising one or more phospholipids. The invention relates to the use of phospholipids in combination with said active principle, to be administered orally for improving its palatability, and to the use of phospholipids in combination with said active principle to be administered orally for the treatment of gastrointestinal irritation disorders and to synergistically improve its anti-ulcer effect.
