Pfizer Inc.;The Regents of the University of California;The Board of Trustees of the Leland Stanford Junior University
发明人:
Isaac J. Rondon,Natasha Crellin,Paul Bessette,Eleonora Trotta,Jeffrey A. Bluestone,Lauren K. Ely,Kenan C. Garcia
申请号：
US16133939
公开号：
US10738113B2
申请日:
2018.09.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
