The Board of Trustees of the Leland Stanford Junior University;Pfizer Inc.;The Regents of The University of California
发明人:
Rondon, Isaac J.,Crellin, Natasha,Bessette, Paul,Trotta, Eleonora,Bluestone, Jeffrey A.,Ely, Lauren K.,Garcia, Kenan Christopher
申请号：
AU2016340989
公开号：
AU2016340989A1
申请日:
2016.10.21
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Ra and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
