AULT, BRIAN,HWANG, CLARA,ORLEMANS, EVERARDUS,PLACHETKA, JOHN R.,SOSTEK, MARK
申请号：
AU2010263304
公开号：
AU2010263304A1
申请日:
2010.06.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present disclosure is directed to a method for treating a disease or disorder in a patient at risk of developing an NSAID-associated ulcer by administering a pharmaceutical composition in unit dose form comprising naproxen, or pharmaceutically acceptable salt thereof, and esomeprazole, or pharmaceutically acceptable salt thereof. The unit dose is designed to release at least a part of the esomeprazole independent of pH (e.g. at a pH of 0 or more) whereas the naproxen is not released until the pH or the surrounding medium is 3.5 or higher.
