SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD.;SINOCHEM CORPORATION
发明人:
CHANGLING LIU,BAOSHAN CHAI,HUICHAO LI,AIYING GUAN
申请号：
ARP130100821
公开号：
AR090334A1
申请日:
2013.03.13
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Diphenylamine as an alternative to antitumor agents. The compounds expressed in formula (1) show strong antitumor activity, especially in treating or alleviating cancer caused by cancer cells in human tissues or organs. Priority cancers include colon cancer, liver cancer, lymphoid cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostate cancer, pancreatic cancer, and bladder cancer. Rectal cancer, osteomaCancer of the nose or stomach. 1. Characteristic 1: diphenylamine substitute compound used as antitumor agent, characterized by its general formula (1),Wherein: R1 chooses the lessor c832131 from H；C₃₋₈ cycloalkyl,Halogenated tar c83218c8331-8328；C83217c833183288a asphalt；C₁₋₈ haloalkylcarbonyl,C₁₋₈ alkoxycarbonyl,C₁₋₈ alkylaminocarbonyl,Cilt alkylthio,haloalquil C tio alquilsulfonilo Calcoxi C -alquilo CAlcoxi c83218c83331s 83288a asphalt layer c83218s 833128；2. Alcoxicarbonil c83217c831c83287a - tar c833218c8331288a；C₁₋₈tio alkylamino, C₂₋₈tio dialkylamino, C₂₋₈ alkenyl,1. C 83228331 asphalt；C₂₋₈ haloalkenyl,C₂₋₈ haloalkynyl,arilo-alquilo C o CO-X-CO RX is selected from (Chr 2) 8345；,CR¹² = CR¹³ or C₆H₄,n = 1-6； R² and R⁶ can be the same or different and are selected, respectively, from H, halogen, CN, NO₂,COOH C (3DO) NR R1. Lease No. 832831, No. c833218331；Halogenated tar c83218c8331-8328；C₁₋₈ alkoxy,C₁₋₈ haloalkoxy,Cilt alkylthio,haloalquil C tio alquenilo C1. C 83228331 asphalt；C₂₋₈ alkylsulfonyl,C83217c833183288a asphalt；C₁₋₈ alkoxycarbonyl,alcoxi C -alquilo C2. Alcoxicarbonil c83217c831c83287a - tar c833218c8331288a；O the following groups not replaced or replaced by 1-5 r83088: arilo, arilmethy, ariloxi, arilamino, arilcarboni lo, arilmethycarbonilo, ariloxicarboni lo, arilaminocarboni o or heteromorph, and the number of substitutes more than 1, r1830808 may be the same or different； R3 and r83099 may be the same or different； 1. Selected from h, halogen,
