A medicament delivery device is presented having a housing, a medicament container holder, arranged movable in relation to the housing and capable of accommodating a medicament container. An activator is arranged in the housing and capable of, upon activation, acting on a medicament container for expelling a dose of medicament, where the activator has a plunger rod, a manually operable dose setting nut rotatably connected to the housing and arranged with first threads. Second threads are arranged on the medicament container holder being arranged to cooperate with said dose setting nut, wherein operation of the dose setting nut will cause the medicament container holder with the medicament container to move towards the plunger rod for setting a dose of medicament to be delivered.