Processes for their preparation, compositions containing Same, Therapeutic uses and combinations with other pharmaceutically Active Ingredients.Claim 1: wherein is a compound of General formula (1), where q is a group of formula (Q1) (Q6)； Z is H or Oh； and is - (CH2) n where n is an integer between 1 and 12 or a divalent Group of formula (2) A1 and A2 independently or are absent. Ccionan among the group consisting alquileno C1 - 6Cicloalquileno heterocicloalquileno C3 and C3 - 8 - 8； b is absent or is selected from the group consisting cicloalquileno heterocicloalquileno C3 C3 - 8, - 8, and heteroarileno arylene or is a group of formula (3)； c is absent or is selected from the group consisting of - or - - or CO -, - C (o) o -, - S, - S (o) -,- S - and (OR) 2 - or - N (R4) is one of the remnants of the group of formulas (4) where it is R4 H or is selected from the group consisting of 8 C1 - C3 alkyl, cycloalkyl - 8 - 8 heterocicloalquilo C3, aryl and heteroaryl； d was selected from the group consisting alquileno C1 - C2 - alquenileno 12, 12 and alquini Leno C2 - 6Optionally substituted with one or more alkyl C1 - 6； R is H or alkyl - C1 - 4； X is - or or - S - H OR； r1 is selected from the group consisting of C3 - 8 cycloalkyl, aryl, heteroaryl, arylalkyl C1 - 6 - 6, heteroarilalquilo C1 and C3 cicloalquil - 8alquilo C1 - 6, optionally substituted with one or more More c1-4 alkoxy； R2 is selected from the group consisting of C3 - 8 cycloalkyl, aryl, heteroaryl,Arylalkyl C1 - 6 - 6, heteroarilalquilo C1 and C1 - C3 - cicloalquil 8alquilo 6, optionally substituted with one or more Atoms of halogen or c1-4 alkoxy； R3 is H or is selected from the group consisting hidroxialquilo C1 - Oh, - 6, - N and - N (r5r6) (R5) Co (r6)； R5 and R6 are independently H or alqui The C1 - 6； and pharmaceutically acceptable salts or solvates thereof.Procesos para su preparación, composiciones que los comprenden, usos terapéuticos y combinaciones con otros ingredientes farmacéuticamente ac
