RENO;BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION; ON BEHALF OF THE UNIVERSISITY OF NEVADA
发明人:
BURKIN, DEAN,WUEBBLES, RYAN
申请号：
CA2919516
公开号：
CA2919516A1
申请日:
2013.09.10
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed herein are a7ß1 integrin modulatory agents and methods of using such to treat conditions associated with decreased a7ß1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an a7ß1 integrin modulatory agent to the subject with muscular dystrophy, wherein the a7ß1 integrin modulatory agent increases a7ß1 integrin expression or activity as compared to a7ß1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing a7ß1 integrin expression by use of the disclosed a7ß1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.
