Reno;Board of Regents of the Nevada System of Higher Education; on Behalf of the University of Nevada
发明人:
BURKIN, Dean,WUEBBLES, Ryan
申请号：
DK13835809
公开号：
DK2892525T3
申请日:
2013.09.10
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
Disclosed herein are ±7²1 integrin modulatory agents and methods of using such to treat conditions associated with decreased ±7²1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an ±7²1 integrin modulatory agent to the subject with muscular dystrophy, wherein the ±7²1 integrin modulatory agent increases ±7²1 integrin expression or activity as compared to ±7²1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing ±7²1 integrin expression by use of the disclosed ±7²1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.
