用作RORγt調節劑之三氟甲基醇农业专利-农业学术服务平台

发明人:: GOLDBERG, STEVEN,高伯格　史蒂芬,高伯格　史蒂芬,VENKATESAN, HARIHARAN,凡卡泰森　哈里哈兰,凡卡泰森　哈里哈蘭,TANIS, VIRGINIA,塔尼斯　维吉尼亚,塔尼斯　維吉尼亞,KINZEL, OLAF,金索　欧拉夫,金索　歐拉夫,GEGE, CHRISTIAN,盖格　克里斯钦,蓋格　克里斯欽,STEENECK, CHRISTOPH,史堤内克　克里斯多夫,史

摘要：: The present invention comprises compounds of Formula I.wherein: X, A1, A2, A3, A4, R1, R2, and R3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.本發明包含式I之化合物其中：X、A1、A2、A3、A4、R1、R2、及R3係定義於說明書中。本發明亦包含一種治療或改善症候群、病症或疾病之方法，其中該症候群、病症或疾病係類風濕性關節炎或乾癬。本發明亦包含一種藉由投予治療有效量之如申請專利範圍第1項所述之至少一種化合物來調節哺乳動物中之RORγt活性的方法。