您的位置: 首页 > 农业专利 > 详情页

TCR SPECIFIQUES DE L'ANTIGENE HA-1 D'HISTOCOMPATIBILITE (H) MINEURE ET SES UTILISATIONS
专利权人:
FRED HUTCHINSON CANCER RESEARCH CENTER
发明人:
BLEAKLEY, MARIE,DOSSA, ROBSON,SOMMERMEYER, DANIEL
申请号:
CA3035075
公开号:
CA3035075A1
申请日:
2017.09.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present disclosure provides compositions and methods for targeting a minor histocompatibility (H) antigen (HA-1H?) to, for example, prevent or manage relapse of a hematological malignancy after allogeneic hematopoietic stem cell transplantation (HCT). Also provided are transgene constructs encoding engineered binding proteins, such as a T cell receptor or a chimeric antigen receptor, optionally encoding additional components such as a co-receptor and/or safety switch. Such transgene constructs can be transduced into an immune cell, such as a T cell, and used as an immunotherapy in a subject having a hematological malignancy or at risk for recurrence of the hematological malignancy (e.g., leukemia, lymphoma, myeloma).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充