Daniel C. Liebler,Lisa J. Zimmerman,Hyoungjoo Lee,Carlos A. Morales Betanzos,Douglas B. Johnson
申请号：
US15899970
公开号：
US20180238904A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure relates generally to the analysis of immune checkpoint proteins involved in cancer. In particular, the present disclosure provides material and methods for determining abundance ratios of various immune checkpoint proteins (e.g., PD-1, PD-L1, and PD-L2) present in a biospecimen sample based on quantification of peak area using mass spectrometry analysis. The methods disclosed herein provide an alternative platform for diagnosing and treating cancer, especially in cases limited by ineffective antibody recognition.
