PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES

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专利权人:

发明人:

SCHUTZ JAN,KARGE REINHARD

申请号：

IN7532/DELNP/2011

公开号：

IN2011DN07532A

申请日:

2011.09.30

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula (I) wherein R is CONH2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H2N CH = C(R) CN (II) is reacted with acetlmidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula (I) is transferred into an acid addition salt, and the transformation of a compound of formula (II) wherein R is CONH2 into a compound of formula (II) wherein R is CN by treatment with POCI3.

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