JOCHHEIM, Claudia,MILLER, Dennis M.,NAIRN, Natalie,STROUD, Mark,BYRNES-BLAKE, Kelly,HANSEN, Stacey J.,NOVAK, Julia E.,WISS, Valorie R.
申请号：
AU2020200116
公开号：
AU2020200116A1
申请日:
2020.01.08
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020200116A120200130.pdf#####ABSTRACT OF THE DISCLOSURE Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided. 11956035 1 (G1Matrs)P102672.AU.160123/40 A Signal in whole brain Tissue 4.5E+07 4.OE+07 L Dorsal cortex 3.5E+07 Dorsal tumor 32.5E+07___ Ventral cortex . 2.5E+07. Ventral tumor 1.5E+071.OE+07 5.OE+06O.OE+00B Whole tissue 12 micron 1380 44.2 40.0 1000 30 30.0 600 20.0 10.0 200 0.233 Si005 Signal SSignal Odyssey White Light Odyssey H&E FIG. 2024/40 C Signal in SmoAl cortex I.OE+059.OE+05 1] Dorsal 7.OE+05 EIVentral 76.OE+05 -__ ___________ i6.OE+05 50.OE+053.OE+05 2.OE+05I.OE+05O.OE+OOFIG. 20 (Cont.)
