AMBROSE, CATHERINE G.;CLYBURN, TERRY A.;MIKOS, ANTONIOS G.
发明人:
AMBROSE, CATHERINE G.,CLYBURN, TERRY A.,MIKOS, ANTONIOS G.
申请号：
CA2497973
公开号：
CA2497973C
申请日:
2003.09.05
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Biodegradable microspheres implanted, injected, or otherwise placed totally orpartially within the body are capable of near-linear controlled release of anantibiotic for a predetermined period of time for the treatment and preventionof infections involving the body. The microspheres are formed of polylactic-co-glycolic acid (PLGA) and an effective amount of antibiotic sufficient toproduce bactericidal levels in body tissues, and may or may not includepolyethylene glycol (PEG). The microspheres exhibit near-linear delivery ofthe antibiotic for at least 4 weeks at levels exceeding the minimum inhibitoryconcentration (MIC) for organisms commonly found to be the cause of infections.
