The ingredients include specific ammonia derivatives for the treatment of skin diffuse diseases or disorders and specific ammonia derivatives for such treatment: 1: a formulated am derivative (1): a-nh-b (1) or a pharmaceutically acceptable salt or nitrous oxide. A solution or derivative thereof for the treatment of diffuse dermatoses or disorders, where a represents a formula group (A1) or (A2),The asterisk symbol indicates the link with other nh-b； in formula group (A1): R1 represents a selected group of hydrogen atoms, halogen, C1-4 tar group, which can be replaced by 1, 2 or 3 selected halogen atoms and hydrogen Xi group substitutes, c. C3-8 cyclopropyl compounds and C3-8 cyclopropyl compounds can be selected to be replaced by 1, 2 or 3 selected halogen atoms and hydrogen Xi substitutes； one group of G3 and G4 is nitrogen atom, the other is CH group； group M is hydrogen atom or drug acceptable catalyst； formula group A2: R1 rsqoe；1. From a group consisting of hydrogen atom, halogen atom, C1-4 tar, C1-4 tar, C3-4 epoxy compound, CF3 and ocf3, R2 and rsqoe； from a group consisting of hydrogen atom, halogen atom and C1-4 tar group； R3 and rsqoe； from a group consisting of coor5 and rsqoe；-CONHR5,tetrazolilo -SO2NHR5 26rsquo y -CONHSO2R5 26rsquoWhere R5 rsqoe； is selected from hydrogen atom and C1-4 linear tar group or branch group； B represents a group of formula (B1) or (B2),A asterisk indicates connection to other a-nh -；In formula group (B1): one G1 group represents a nitrogen atom or a CRC group, another represents a CRC group； G2 represents a nitrogen atom or a CRD group； R2 represents a group selected from hydrogen, halogen atom or hydrogen group, C1-4 tar group can be selectively replaced by 1, 2 or 3 selected halogen atoms and hydroxyl substitutes, C1-4 alcox group, and 1, 2 or 3 selected halogen atoms and hydroxyl substitutes, And C3-8 cyclopropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylpropylp
