GARARD, MARC,WARRINGTON, JEFFREY MICHAEL,LU, PU,PING - ASHCRAFT, LUKE,COLLIBEE, SCOTT EMILE,MALIK, FADY,MORGAN, BRADLEY PAUL,MIHARA, KAYOKO,OHE, MUNEMICHI,KIYOHARA, HIROSHI,SAITO, TOMOYUKI,YAMAKI, SUS
申请号：
ARP170100336
公开号：
AR107592A1
申请日:
2017.02.10
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
4. It can be used as the active component of the pharmaceutical component, especially the tetrahydroisomer compound used to prevent or treat a disease or meet the conditions of inhibiting modulation of scabies. For example, it can be modulated by one or more fast skeletal skin skin, Yang Qi element, tropina C, tropina I and tropina T through the modulation of fast skeletal muscle Botox E.coli.And these fragments and their variants 4. Tetrahydroisotopic compounds can be used to prevent or treat (1) neuromuscular disorders, (2) voluntary muscular disorders, (3) SNC sections where muscle weakness, atrophy and fatigue are significant symptoms, (4) muscle symptoms caused by systemic disorders, (5) Pelvic floor and urinary / anal sphincter dysfunction. 1. Characteristic requirement 1: a compound whose characteristic is formula (1),or a salt thereof, where, X¹: C-R¹¹ or N； X²: C-R¹² or N； R¹¹: i) H, ii) halogen, iii) -CN, or iv) -O-C₁₋₆ alkyl； R¹²: H or halogen； R¹: i) H, ii) C₁₋₆ alkyl which may be substituted with one or more substituents selected from the group consisting of halogen, and pyrazolyl, iii) C₂₋₆ alkenyl, or iv) -OR⁰；R²: i) C₁₋₆ alkyl which may be substituted with one or more substituents selected from the group consisting of -OR⁰,Halogen, coordination 830404,-Conr,Phenyl, which can be replaced by one or more alternatives selected from group 1,and heteroaryl which is selected from the group consisting of pyridyl, pyrazolyl, imidazolyl, thiazolyl, thiadiazolyl, thienyl, oxazolyl, isoxazolyl, and triazolyl, where the heteroaryl may be substituted with one or more substituents selected from the group G²,ii) C₂₋₆ alkenyl, iii) C₂₋₆ alkynyl, iv) -OR⁰,v) -NR R(VI) coordination 830404；or vii) phenyl； R²¹: H or C₁₋₆ alkyl； R²²: i) C₁₋₆ alkyl which may be substituted with one or more phenyl, or ii) phenyl； R²³: i) H, or ii) C₁₋₆ alkyl which may be substituted with one or more -OH； R²⁴: i) C₁₋₆ alkyl that can be substituted with one or more phenyl that can be substitu
