PROBLEM TO BE SOLVED: To provide a novel compound that is useful as a therapeutic agent and/or a preventive of a mentality nervous disease resulting from beta amyloid.SOLUTION: A compound shown by formula (I) or a salt thereof is disclosed [in the formula, X1, X2 and X3 identically or differently denote a nitrogen atom or CH or the like Y denotes a single bond, -CH=CH- or the like Z1 and Z2 identically or differently denote CH, a nitrogen atom or the like R1, R2 and R3 identically or differently denote a hydrogen atom, a C1-6 alkyl or the like R4 denotes a hydrogen atom, a C1-6 alkoxy or the like R5 denotes aryl, heteroaryl or the like R6, R7 and R8 identically or differently denote a hydrogen atom, a C1-6 alkyl or the like n denotes an integer of 0-2].COPYRIGHT: (C)2014,JPO&INPIT【課題】ベータアミロイドに起因する精神神経疾患の治療剤及び/又は予防剤として有用な新規化合物の提供。【解決手段】式(I)で表される化合物又はその塩[式中、X1、X2及びX3は、同一又は異なって、窒素原子、CH等を表し、Yは、単結合、-CH=CH-等を表し、Z1及びZ2は、同一又は異なって、CH、窒素原子等を表し、R1、R2及びR3は、同一又は異なって、水素原子、C1-6アルキル等を表し、R4は、水素原子、C1-6アルコキシ等を表し、R5はアリール、ヘテロアリール等を表し、R6、R7及びR8は、同一又は異なって、水素原子、C1-6アルキル等を表し、nは0~2の整数を表す]。【化1】【選択図】 なし
