ANTHONY R. HAIGHT,CRISTINA FISCHER,DELIANG ZHOU,ERIC SCHMITT,GEOFF ZHANG,KATHERINE HEEMSTRA,MICHAEL FICKES,NATHANIEL CATRON,PING TONG,YESHWANT SANZGIRI
申请号:
BRPI1014492
公开号:
BRPI1014492A2
申请日:
2010.04.30
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.