GEORGE L. GABOR MIKLOS MIKLOS,GEORGE L GABOR MIKLOS MIKLOS
申请号：
BR112018000206
公开号：
BR112018000206A2
申请日:
2016.07.11
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to the generation of an atomic therapeutic indicator (ati) for a test sample by quantifying manganese, in voxels, of a three-dimensional (3d) region of the sample, wherein the 3d region is defined topographically by the x coordinates. 'xy'xz. Ati is used to assess responsiveness to radiotherapy, ie the sensitivity or resistance to radiation treatment of a cancer, ie a tumor / neoplasm. In a preferred embodiment, the present invention relates to a method for generating ati, assessing the radiotherapy responsiveness of an ati-based tumor / neoplasia and, according to the assessment, whether or not to treat the tumor with radiation. The present invention also relates to a method for determining whether cancer recurrence is likely after radiation treatment, comprising quantifying the level of manganese in voxels of a 3d region of a cancer test sample and determining the frequency of regions. of high metallomic (hmrs) in cancer, where high frequency of hmrs is indicative that cancer is likely to recur and low frequency of hmrs is indicative that cancer is unlikely to recur, and associated methods of treatment. The invention further relates to a method for determining radiotherapy responsiveness of a melanoma, wherein the method comprises determining the level of melanin in a melanoma test sample.a presente invenção refere-se à geração de um indicador terapêutico atômico (ati) para uma amostra em teste pela quantificação de manganês, em voxels, de uma região tridimensional (3d) da amostra, em que a região 3d é definida topograficamente pelas coordenadas x'xy'xz. o ati é utilizado para avaliar a responsividade à radioterapia, ou seja, a sensibilidade ou resistência ao tratamento com radiação de um câncer, ou seja, um tumor/uma neoplasia. em uma modalidade preferida, a presente invenção refere-se a um método para geração do ati, avaliando a responsividade à radioterapia de um tumor/uma neoplasia com base no ati e, de acordo com a avaliação, tra
