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作為因子Xa抑制劑之雜芳基-羧酸(胺磺醯基烷基)醯胺-衍生物
专利权人:
SANOFI-AVENTIS
发明人:
WAGNER, MICHAEL,王麦克,王麥克,URMANN, MATTHIAS,游马斯,游馬斯,WEHNER, VOLKMAR,魏弗玛,魏弗瑪,LORENZ, MARTIN,罗马丁,羅馬丁,BAUER, ARMIN,巴亚明,巴亞明,NAZARE, MARC,那萨玛,那薩瑪,MATTER, HANS,马汉斯,馬漢斯
申请号:
TW095117566
公开号:
TWI376377B
申请日:
2006.05.18
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The present invention relates to compounds of the formula I, in which R1; R2; R3; V; G1 and G2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa, and can in general be applied in conditions in which an undesired activity of factor Xa is present or for the cure or prevention of which an inhibition of factor Xa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.本發明係有關一種式I化合物;(I);其中R1;R2;R3;V;G1與G2如申請專利範圍中之定義。式I化合物為有價值之醫藥活性化合物。其具有強力抗血栓效應,適合例如:治療及預防如:血栓性栓塞疾病或再狹窄之心血管病變。其為凝血酵素因子Xa之可逆性抑制劑,通常可用於出現因子Xa不希望活性時之病症或用於治療或預防希望抑制因子Xa之病症。本發明尚有關一種製備式I化合物之方法,其用途,特定言之作為醫藥之活性成分之用途,及含其之醫藥製劑。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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