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Stable pharmaceutical form of the anti-cancer drug
专利权人:
INSTYTUT CHEMII ORGANICZNEJ PAN;WARSZAWSKIE ZAKLADY FARMACEUTYCZNE "POLFA" SPOLKAAKCYJNA;AKADEMIA MEDYCZNA
发明人:
JANICKI STANISLAW (ZOMREL),JANICKA ALICJA MARIA (DEDIC),JANICKA-KOKITKO MALGORZATA (DEDIC),SZNITOWSKA MALGORZATA,KARAS WLADYSLAW,MROCZEK ZDISLAW,TYRALA ANDRZEJ,CZARNECKA IWONA,SZNITOWSKA MALGORZ
申请号:
SK6292003
公开号:
SK287850B6
申请日:
2001.10.19
申请国别(地区):
SK
年份:
2012
代理人:
摘要:
The method for production of the stable pharmaceutical form of paclitaxel as an anticancer drug consists in dissolution of crystalline paclitaxel in a neutral organic solvent selected from the group comprising acetonitrile, dioxane, ethanol, or a mixture of those solvents, with possible addition of water, providing that the content of individual solvents in the mixture is in the range of 5 % to 95 %, while the content of water is in the range of 0 to 60 %; the resulting solution is possibly filtered, frozen, and solvents are removed by sublimation under reduced pressure, at a low temperature, and thereafter the preparation is possibly distributed into doses in conditions assuring its sterility.The method for production of the stable pharmaceutical form of paclitaxel as an anticancer drug consists in dissolution of crystalline paclitaxel in a neutral organic solvent selected from the group comprising acetonitrile, dioxane, ethanol, or a mixture of those solvents, with possible addition of water, providing that the content of individual solvents in the mixture is in the range of 5 % to 95 %, while the content of water is in the range of 0 to 60 %; the resulting solution is possibly filtered, frozen, and solvents are removed by sublimation under reduced pressure, at a low temperature, and thereafter the preparation is possibly distributed into doses in conditions assuring its sterility.
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