Marti Bartra Sanmartí,Ramón Berenguer Maimó,Jordi Benet-Buchholz,Lluis Solà I Carandell
申请号：
US12863708
公开号：
US09056864B2
申请日:
2009.01.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C1-C4)-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof b) isolating the crystalline form of abacavir that appears in the prior step and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections.
