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Formulations of recombinant furin
专利权人:
Ken Franke;Meinhard Hasslacher;Catherine White;Andrzej Citkowicz
发明人:
Meinhard Hasslacher,Andrzej Citkowicz,Catherine White,Ken Franke
申请号:
US13488324
公开号:
US08877473B2
申请日:
2012.06.04
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present application provides stabilized formulations of furin (e.g., rfurin) containing a sugar, sugar alcohol, and/or non-ionic surfactant. As compared to non-stabilized compositions, the furin formulations disclosed herein retain greater amounts of furin activity and monomeric furin content, while reducing furin aggregation when stored and/or subjected to mechanical stress. Also provided are methods for stably diluting furin (e.g., rfurin) compositions.
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