A system includes a controller that receives a blood pressure signal and an oxygen saturation signal. The blood pressure signal represents a non-invasive measure of blood pressure. The oxygen saturation signal represents a non-invasive measure of oxygen saturation. The controller generates an autoregulation status signal representing a status of cerebral autoregulation. The autoregulation status signal is based, at least in part, on a relationship between the measured blood pressure and the measured oxygen saturation. An exemplary method may include receiving the blood pressure signal and the oxygen saturation signal, defining a relationship between the measured blood pressure and the measured oxygen saturation, determining an autoregulation status based at least in part on the defined relationship, and generating an autoregulation status signal representing the determined autoregulation status.