A non-invasive pressure monitoring system includes a first sensor placed proximate to a perfusion field of an artery receiving blood which emanates from the cranial cavity is configured to measure pulsations of the artery receiving blood which emanates from the cranial cavity artery and generate first output signals. A second sensor placed proximate to a perfusion field of an artery which does not receive blood emanating from the cranial cavity configured to measure pulsations of the artery which does not receive blood emanating from the cranial cavity and generate second output signals. A processing subsystem responsive to the first output signal and the second output signal is configured to calculate the time shift associated with the highest cross-correlation of the two signals, or the phase shift or magnitudes of different frequencies included in the first output signals and the second output signals and determine intracranial pressure of the human subject from a time shift of the cross-correlation with the highest value.
