BAI YAO ZHI DA (BEIJING) NANOBIO TECHNOLOGY CO.; LTD.
发明人:
WANG, LIYUAN,王力源,WANG, MENG,王萌
申请号：
TW108124772
公开号：
TW202005638A
申请日:
2019.07.12
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
Nucleic acid nanoparticles, a pharmaceutical composition comprising same, a drug comprising doxorubicin and a preparation method therefor. The nucleic acid nanoparticles comprise a nucleic acid structural domain, the nucleic acid structural domain comprising an a sequence, a b sequence and a c sequence； the a sequence comprises an al sequence or a sequence in which an al sequence that has undergone at least one base insertion, deletion or substitution； the b sequence comprises a b1 sequence or a sequence in which a b1 sequence had undergone at least one base insertion, deletion or substitution； and the c sequence comprises a c1 sequence or a sequence in which a c1 sequence has undergone at least one base insertion, deletion or substitution. The nucleic acid nanoparticles may, by means of containing the three described sequences or variants thereof, not only self-assemble to form a nucleic acid structural domain but may also serve as a carrier.本發明提供了一種核酸奈米顆粒、包含其的藥物組合物、含阿霉素的藥物及其製備方法。該核酸奈米顆粒具有核酸結構域，核酸結構域包含a序列、b序列和c序列，a序列包含a1序列或者a1序列發生至少一個鹼基插入、缺失或替換的序列，b序列包含b1序列或者b1序列發生至少一個鹼基插入、缺失或替換的序列，c序列包含c1序列或者c1序列發生至少一個鹼基插入、缺失或替換的序列。該核酸奈米顆粒通過包含上述三條序列或其變異序列，不僅能夠自組裝形成核酸結構域，而且可以作為載體掛載和遞送藥物。
